Synonyms
aHUS
Inherited Hemolytic-Uremic Syndrome

Disorder Subdivisions
None

General Discussion
Atypical hemolytic uremic syndrome (aHUS) is an extremely rare group of disorders of the kidneys. It is a distinctly different illness from hemolytic uremic syndrome caused by the bacterium E.coli 0157:h7 (Stx HUS). While Stx HUS typically is preceded by a flu-like illness and is associated with that particular strain of E. coli bacterium, there is substantial evidence that aHUS is a genetic disorder.

Atypical hemolytic uremic syndrome may become a chronic condition, and patients with aHUS may experience repeated attacks of the disorder. When children with Stx HUS recover from the life-threatening initial episode, they are likely to respond well to supportive treatment and to make a good recovery. Children with aHUS are much more likely to develop chronic serious complications such as kidney failure and severe high blood pressure.